For example, in a study by Asenbaum et al., single photon emission computed tomography (SPECT) showed increased blood flow in the right hemisphere and decreased blood flow in the thalamus during REM sleep in patients with narcolepsy. ![]() Some Previous neuroimaging studies have attempted to clarify the mechanisms of the brain dysfunction in narcolepsy. Dysregulation of the hypocretinergic system plays an important role in the pathogenesis of human narcolepsy-cataplexy. Narcolepsy is a disabling sleep disorder characterized by excessive daytime sleepiness (EDS) and abnormal rapid eye movement(REM) sleep manifestations. Ĭompeting interests: The authors have declared that no competing interests exist. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.įunding: This work was supported by Japan Society for the Promotion of Science (JSPS) KAKENHI Grant Number 21791161, Grant-in-Aid for Young Scientists (B). Received: Accepted: OctoPublished: November 28, 2013Ĭopyright: © 2013 Nakamura, et al. PLoS ONE 8(11):Įditor: Oscar Arias-Carrion, Hospital General Dr. ![]() Citation: Nakamura M, Nishida S, Hayashida K, Ueki Y, Dauvilliers Y, Inoue Y (2013) Differences in Brain Morphological Findings between Narcolepsy with and without Cataplexy.
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